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Herbs & Supplements
Grape Seed Extract
Scientific Name: Grape Seed
Other Names: Muscat, Red Wine Extract, Vitis vinifera
What interactions should I watch for?
Prescription Drugs
Grape seed extract possibly may increase the time blood needs to clot. When it is taken with antiplatelet or anticoagulant drugs, the effect of the drug may be increased, resulting in uncontrolled bleeding.
- Antiplatelets include clopidogrel and Ticlid
- Anticoagulants include heparin and warfarin
Non-prescription Drugs
Grape seed extract can reduce the ability of blood to clot after an injury. Aspirin can also decrease clotting, so grape seed extract should not be taken orally at the same time as aspirin.
In one small study, blood pressure increased for individuals taking both vitamin C and grape seed extract. While the increases were not dramatic, individuals with high blood pressure may want to check blood pressure more often if grape seed extract and vitamin C are taken together. If blood pressure rises, either vitamin C or grape seed extract or both may need to be stopped.
Herbal Products
Theoretically, if grape seed extract is used with other herbs that affect blood clotting, bleeding may occur. Some of the most common herbal products that might inhibit blood clotting are:
- Danshen
- Devil's Claw
- Eleuthero
- Garlic
- Ginger (in high amounts)
- Gingko
- Horse Chestnut
- Panax Ginseng
- Papain
- Red Clover
- Saw Palmetto
Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals. For specific information on how grape seed extract interacts with drugs, other herbals, and foods and the severity of those interactions, please use our Drug Interactions Checker to check for possible interactions.
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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.
In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.
This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.
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What interactions should I watch for?
